My research focuses on the development and application of image-guided, non-invasive brain stimulation (NIBS) techniques to causally investigate the physiological underpinnings of brain neurological disorders. Ultimately, I aim to translate this work into novel brain stimulation therapies to alleviate neurological symptoms. 

Throughout my research journey, I have employed and currently employ a combination of non-invasive brain stimulation methods, including transcranial electrical stimulation (tDCS, tACS, and tRNS), navigated transcranial magnetic stimulation (TMS), focused ultrasound (FUS), MRI, and biophysical modeling for individualized stimulation. These techniques are integrated with electrophysiological approaches, such as electroencephalography (EEG) and electromyography (EMG), and neuroimaging (MRI) to optimize both research and clinical interventions. 

Active Principal Project

Collaborations

EXPERIMENTAL PHYSIOLOGY 

• Deciphering Immediate Transcranial Evoked Potentials (iTEPS): At the DRCMR (Denmark), I contribute to understanding the physiological origins and potential implications of immediate transcranial evoked potentials (iTEPs) combining TMS-EEG-EMG-FUS methodologies. See for more information: https://github.com/XavierCorominas/iTEPs

• Impact of weak magnetic fields in the human brain. With the Paris Brain Institute (France), I contribute to investigate the oscillatory functional effects of very weak magnetic fields on the human brain for neuromodulation purposes. See for more information: DOI: https://doi.org/10.1101/2025.02.04.636500

METHODOLOGICAL AND SOFTWARE DEVELOPMENT 

• E-field simulation & EEG analyses tools. At the DRCMR and in collaboration with the Paris Brain Institute and Aalto University (Finland), i contribute to develop new computational methods to combine e-field biophysical modelling and tractography to better estimate source eeg reconstructed signals for TMS-EEG studies. See for more information: https://github.com/XavierCorominas/EPICURUS_E_field_eeg_spatial_filtering

• FUS planning and simulation. At the DRCMR, i contribute to develop new computational methods to combine ultrasound biophysical modelling  with finite element models, fMRI, tractography and EEG to better plan and understand FUS effects in the humans brain. 

• Simulation monitoring of DBS electrode polarization by exogeneous TMS/tCS/FUS fields. See for more information: https://github.com/XavierCorominas/E_field_DBS 

CLINICAL INTERVENTIONAL 

•  E-BRAIN stroke and tDCS project: with the hospital Joan XXIII of Tarragona (Spain) i contribute to explore the potential role of multifocal network tDCS stimulation for post-stroke motor and cognitive recovery. See for more information: https://doi.org/10.1186/s13063-023-07680-8

Ongoing projects with supporting contributions: 

cRETMS: at the Paris Brain Institute I collaborate to investigate the role and causal implications of the cerebello-talamo-cortical networks for reward based motor learning.  https://doi.org/10.1016/j.brs.2023.01.619

WONDERMIND: at the Paris Brain Institute I collaborate to understand the causal role of prefrontal oscillatory systems in mind-wondering and its possible implications in cognitive pathological populations. 

STIM-SD: at the Hospital Pitié-Salpêtrière (France) I collaborate to investigate the potential clinical efficacy of tDCS as a treatment for primary progressive aphasia in a longitudinal pre-clinical trial.  https://doi.org/10.1016/j.brs.2023.01.609 

HEMIANOTACS: at the Hospital Pitié-Salpêtrière (France) I collaborate to investigate the anatomical, functional and oscillatory mechanisms underlying post-stroke vision loss and potential applications of tACS as a clinical treatment. https://doi.org/10.1016/j.brs.2023.01.404